VDR is a gene which codes for a protein that acts as a receptor vitamin D that regulates bone formation and calcium absorption. A variant of the gene (rs2228570, FokI polymorphism) is associated with decreased bone mineral density among prepubescent girls of white background.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and temporal on-and-off occupancy of the VDRE between the two components. It is also controlled by chromosomal positioning and binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes possess an identifiable VDRE within their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for gescheftmarketing.de/2021/12/29/gaining-knowledge-and-business-direction-2/ data and documents that are relevant to legal transactions, business or proceedings with restrictions on viewing printing, downloading, or viewing. It uses a central server as well as an extranet connection which is an Internet connection with restricted access, which allows controlled login time periods during which users are able to browse the documents and data.
VDRs are most commonly used by investment banks and companies involved in mergers or acquisitions. They require to share information in a transparent manner with potential investors and buyers. Due diligence can also require a large amount of data. Life science companies also use VDRs to keep everything from clinical trial results to HIPAA documentation.